Many of the issues encountered by start-ups are quite similar. Learn new solutions for your business through our case study program. The company will present an Executive Overview and their key challenges. Then an assembled “Board of Directors” takes over and suggests possible solutions. But you can too — the audience often sees even better solutions.
Our program spotlights Nanomedical Diagnosics and their unique challenges. Nanomedical Diagnostics has come up with a Field Effect Biosensing (FEB) technology that provides real-time, label-free kinetic binding and affinity data.
Kinetic binding and characterization of biotherapeutic candidates is an important part of screening and selection during drug discovery. The ease and speed with which this information is obtained directly affects decisions about whether a candidate is suitable for further research. Thus there are important considerations to be made when choosing a method for analyzing biophysical data.
Nanomedical Diagnostics has created an innovative solution to provide real-time kinetic characterization with a device that is barely larger than a cell phone. AGILE R100 is a benchtop label-free assay built with proprietary Field Effect Biosensing (FEB) technology that enables detection even with small amounts of starting material, low concentrations, and weak biomolecular interactions.
How it Works
AGILE R100 uses a graphene biosensor chip built with proprietary Field Effect Biosensing (FEB) technology. FEB is an electrical technique that measures the current across a field effect graphene biosensor to which targets are immobilized (Figure 1). Any interaction or binding that occurs on the surface causes a change in conductance that is monitored in real-time (Figure 2), enabling accurate kinetic, affinity, and concentration measurements.
“A baseline read is taken with AGILE R100 prior to immobilizing the target. As the target is immobilized to the surface of the AGILE biosensor chip, the change can be seen in the built-in software’s sensorgram. As free-in-solution analyte is introduced, the association between target and analyte can be viewed in the real-time sensorgram as binding occurs. When dissociation occurs, the response decreases, which is also shown in the sensorgram.” See the video below to see how the AGILE R100 is used.
5:30: Registration, Networking, food and drinks
7:30: Audience Q & A
8:00: Program Concludes, Networking, Coffee & Dessert until 8:30
REGISTRATION & COST
MITEF Members and MITEF Sponsors: Free
MIT Alums: $50
NOTE: Online Registration ends at 11AM, the day of the event. If you register online after 11AM, you will be charged $75, the on-site price.
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